A unique video showingthe process of memory formation in the brain. Observation of the brain was carried out using molecules that glow with fluorescent light. Scientists note that the experiment will help to better understand the principle of the brain.
Researchers at the College of Medicine named afterAlbert Einstein University of Yeshiva University describes his work as "a manifestation of previously unseen technological mastery in animal experiments." During the study, scientists observed the movement of molecules that received fluorescent labels. This allowed in real time to track the processes of remembering information in brain cells, the newspaper The Daily Mail writes.
Conducting such experimentscomplicated by the high sensitivity of neurons to any third-party interventions. American scientists did not take risky actions and refused to introduce artificial genes into the experimental mouse's body, which could disrupt the functioning of neurons and cast doubt on all the conclusions made.
In the experiment described in two articles forScience magazine, scientists have stimulated hippocampal neurons, where memories are born and stored. Then they observed the formation of fluorescence beta-actin mRNA molecules in the nuclei of neurons and their journey through the branching processes of a nerve cell.
As it turned out, neurons use complexa strategy for managing the proteins responsible for the formation of memory. Thus, the activity of mRNA molecules is regulated by the poorly studied process of “masking” and “unmasking”, which allows the beta-actin protein to be synthesized in certain amounts at the right time and in the right place.
Scientists continue to improve technologyvisualization of neurons. Since the hippocampus is deep in the brain, researchers are hoping to develop fluorescent proteins that emit infrared light that can pass through tissue.