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Successful animal trials of mRNA-based HIV vaccines have been carried out


Scientists from the USA have tested the mRNA of the vaccinefrom HIV in animals. The test results showed that vaccinated macaques had a 79% lower risk of contracting HIV compared to unvaccinated animals. The study was carried out in the laboratories of the US National Institute of Allergy and Infectious Diseases (NIAID), and the hybrid virus (SHIV) was used for the experiment, since macaques are immune to the standard "human" HIV virus.

As a result of testing, it was recorded thatthe body starts making antibodies more efficiently and boosts the cellular immune response. The safety of the vaccine for animals has also been confirmed.

The study was led by a doctor of medical sciencesfrom the NIAID Immunoregulation Laboratory by Paolo Lusso. The American biotechnology company Moderna, which specializes in the creation of drugs based on messenger RNA (mode / RNA or mRNA), took part in the development of the vaccine.

The principle of operation of the created drug is based ondelivery of encoded information to the cells of the body that stimulates the production of the main HIV proteins: Env and Gag. As a result, the body of the vaccinated animal began to actively create virus-like particles (VLP), which cause a protective response of the immune system. The VLPs themselves do not infect a patient because they do not carry the full genetic code of HIV.

During testing, macaques were injected with highdoses of mRNA vaccine. The experimental animals did not show any deviations in behavior, except for a partial loss of appetite. At the 58th week of the experiment, all vaccinated macaques developed neutralizing antibodies against most of the 12 HIV strains. The introduction of the vaccine also stimulated the body's immune response, leading to the activation of T-helper cells.

At 60 weeks of testing, two groups of macaques(vaccinated and control group with unvaccinated animals) were regularly injected with strains of HIV. In the 13th week of this testing phase, in a group of seven vaccinated animals, two macaques remained completely uninfected. The rest of the vaccinated animals, on average, fell ill at the 8th week of the experiment. In the non-vaccinated control group, the animals became infected as early as the third week.