The tooth fairy still exists and lives inKyoto University. The latest developments of a group of Japanese scientists have revived the hopes of adults for the restoration of seemingly irretrievably lost teeth.
Testing by a team of scientists from Kyotothe University and Fukui University has focused on the ability of antibodies to stimulate tooth growth. The subjects used were mice suffering from dental agenesis - congenital absence of one or more teeth. According to statistics, a similar disease is inherent in humans: approximately 1% of people have fewer or more than 32 teeth.
Scientists have investigated the genetic causes of the appearancetoo many teeth to understand how adult teeth can be regenerated. According to scientists, molecules responsible for the development of teeth have already been identified. Among them, bone morphogenetic proteins (BMP) are distinguished. When molecules interact, Wnt signaling is involved.
BMP and Wnt are involved in more than just tooth development.They regulate the growth of many organs and tissues even during the formation of the embryo. Scientists investigated genes that suppress the development of BMP and Wnt and selected the safest gene USAG-1, the suppression of which promotes tooth growth.
During the experiment, the researchers set the goalto establish whether suppression of one USAG-1 gene is sufficient to grow new teeth. The result of the research was the growing of additional teeth in mice. At the next stage, the scientists tested the techniques on ferrets, and in the future they plan to move on to experiments on pigs and dogs.