General, Research, Technology

Scientists have linked the rate of aging with intestinal microflora

Aging is a natural process from which,Unfortunately, do not go anywhere. All living organisms are arranged in such a way that sooner or later they begin to "exhaust their resources and wither." But this does not mean that there is no need to fight or even study such mechanisms. And sometimes discoveries in this area can seriously surprise. For example, not so long ago, a group of researchers from Singapore found a connection between the rate of aging and the state of intestinal microflora.

Is it possible to defeat aging with microflora?

How is microflora associated with aging?

International Research Groupled by Nanyang University of Technology, Singapore (NTU Singapore), found that microorganisms living in the gut can affect aging, which could lead to the development of food-based treatments. All living organisms, including humans, coexist with billions of microbes living both outside and inside. A study that took 20 years found that intestinal bacteria play an important role in nutrition, physiology, metabolism, and even in aging processes. Using laboratory mice, a team led by Professor Sven Pettersson transplanted the intestinal microbes of old mice (they were 24 months old) young (6 weeks old), whose microflora was not so "old".

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A team of scientists has shown that the activity of the nervousthe system is due to the enrichment of intestinal microbes that produce a specific short-chain acid belonging to the class of butyrates (which have nothing to do with “thereby” butyrate). Butyrates are produced by microbial fermentation of dietary fiber in the lower intestine and stimulate the production of the longevity hormone FGF21, which plays an important role in regulating the energy and metabolism of the body. With age, its production decreases.

It turned out that the bacteria of old mice turned out to beable to support the development of the nervous system in young people. And now we can imitate the neurostimulating effect, just using an analog of butyrates. - said Professor Pettersson. This is an amazing and very interesting observation. These results will lead us to examine whether microflora can indirectly support recovery in situations such as stroke, spinal cord injuries, and aging.

The team also investigated the effect of transplantation.intestinal germs from old to young mice on the function of the digestive system. With age, the viability of the cells of the small intestine decreases, and this is due to a decrease in the production of mucus, which makes the cells of the intestine more vulnerable to damage. However, the addition of butyrate helps to better regulate the function of the intestinal barrier and reduce the risk of inflammation.

Scientists have discovered that mice that receivedmicroflora from old donors, had longer intestinal villi. The discovery shows that intestinal microbes can compensate and support an aging body through positive stimulation. This points to a new potential method to combat the negative effects of aging by simulating the enrichment and activation of butyrates. Want to know more? Subscribe to our page in Yandex.Zen.

We can imagine future human studies where we will test the ability of foods to prevent aging.

Interestingly, the germs of an older animal are betterfeel in young individuals. This suggests that the microflora during aging is modified in order to compensate for the accumulating deficiency in the host body. The results obtained contribute to an understanding of the relationship between the microbiome and its host, and lay the foundation for the development of methods and drugs related to maintaining the proper functioning of microflora and the fight against str.