California experts have found a way tostop pregnancy for a certain period or pause. So far, scientists have managed to do this only for 30 days, after which the fetus developed in a completely natural way.
Researchers from the University of California atIn the course of studying the processes of formation of rodent embryo, it seemed to be impossible: they managed to temporarily completely stop the development of the fetus, and then restart this process. In other words, the scientists managed to “put the pregnancy on hold”. After the “removal from the pause” and delivery, the offspring that were born were completely healthy.
It is worth noting that thisthe pause process is not yet possible. Researchers managed to slow down the development of the fetus for a period of 30 days. In this case, the developmental stage at which the embryo is located should not be later than the blastocyst stage.
The most interesting thing is that the body can andindependently carry out such a function. This is called "diapause." This condition occurs due to a threat to the life of the fetus from external conditions or if the nutrition of the mother, and therefore the fetus, stops abruptly. This process is controlled by a protein called mTOR. Increasing the concentration of inhibitors of this protein and allows you to increase the time of "pause".
According to scientists, such a procedure will not helponly in embryology, but also in the fight against cancer and the aging of the body. The fact is that cancer and stem cells can also be paused. This may open a new chapter in the treatment of cancer and the study of stem cells. Scientists argue that increasing the length of the “pause” is possible, but in this case, the fetus may require a lot of nutrients, which can affect the health of the mother.
Like many discoveries, this was made by accident. According to Aidan Bulut-Karsioglu, the lead author of the study,
“The discovery came as a surprise. We intended to study how suppression of mTOR slows down the growth of blastocyst cells, rather than finding a way to hibernate the embryos. Subsequent experiments showed that embryonic stem cells obtained from an embryo at the blastocyst stage can also be immersed in a state of suspended animation by inhibitors of cell growth regulator. Apparently, the drugs act by reducing the activity of the gene in most of the genome, with the exception of a few dominant genes, which in themselves can suppress the activity of others. This is a prime example of the power of fundamental science. We did not look for ways to stop the development of the blastocyst or mimic diapause. "We did not try to create an effective therapy against cancer or to develop more effective methods for tissue regeneration or organ transplantation."