According to the World Health Organizationfrom 3 to 5 million cases of diseases of various types of influenza virus are observed annually in the world, and up to 650,000 cases are fatal. Unfortunately, even in the modern world, science has not yet invented a universal medicine for the most common "seasonal disease." This is explained by the fact that the virus mutates easily, which forces experts to create more and more new types of vaccines. In this case, the principle of vaccination is based mainly on the prevention of the disease. But she does not guarantee that you will not eventually catch any new form of the virus.
International team of scientists from the USA, the Netherlandsand Belgium recently published an article that describes in detail the principle of the experimental drug JNJ4796, created on the basis of special selected molecules that mimic the behavior of neutralizing antibodies. These molecules bind to the hemagglutinin of the virus (a protein on the surface of the viral particle) and neutralize the serotypes of the influenza A virus, blocking its spread throughout the body.
Laboratory tests of the drug were carried out onmice infected with lethal doses of influenza virus. First, the drug was administered to rodents at a dose of 50 and 10 mg / kg a day before infection, and then at the same dosage for seven consecutive days. The drug contributed to the normalization of the state of rodents, but they continued to lose weight. Then the scientists decided to change the dose, reducing them to 5 and 15 mg / kg, but increasing the number of their admission to two times a day. These proportions guaranteed the survival of the mice.
As the scientists note, the molecule has obstructedthe development of influenza virus in the body, triggering the mechanism of recovery even before the infection spread. As a result, the rodents that were injected with the molecule recovered.
Additional vaccine studies have been conducted.on laboratory-grown human lung tissue cells. The results were also positive - the drug allowed to completely get rid of viral particles. All this opens up the potential for drug testing involving human subjects.
“If you told me 10 years ago thatsuch molecules will appear, I would very much disbelieve it. Nevertheless, the molecules we have created prove that they are able to behave like very powerful antibodies, ”said Ian Wilson, one of the co-authors of the study.
The next step in the study of a potential new method of combating influenza should be an experiment involving people.
You can discuss the news in our Telegram-chat.