Recently, pharmacists are more and moreConcerned about the appearance of so-called superbugs - microorganisms that are resistant to most known antibiotics. And to destroy them, you need to create "superantibiotics." This is exactly what a group of Danish bacteriologists did.
According to Nature, Dr. Hans Christian Graham of Genentech leads the study. Development is carried out under the project G0775.
According to one classification, bacteria are divided into 2type: gram-positive and gram-negative. The former in their structure have an external membrane, which prevents the penetration of foreign agents inside. This is what gives them stability, but peptidoglycan, which is a target for antibiotics, is located on the surface of this membrane. Bacteria from the second category also have peptidoglycan, but it is “hidden” between two membranes, which makes it extremely difficult to combat such microorganisms.
Already today there are some“Superantibiotics”, which are based on a substance of the arylomycin class, which block enzymes that are important for bacterial activity, penetrating through cell walls. The new G0775 molecule is much more effective than the existing ones. It has much better permeability. G0775 has already been tested on a 13 antibiotic-resistant strain of Klebsiella Pneumoniae. And G0775 showed high efficiency. But, despite the positive results, the creation of a new medicine is still a long way off. As the researchers note,
“It is too early to argue that the discovery of a new typea compound capable of blocking signaling processes will turn medicine upside down soon. Similar antibiotics appear very rarely. Now we will continue to modify G0775 to destroy other strains of bacteria that are no longer affected by conventional antibiotics. ”
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