One of the most unpleasant manifestations of the diseaseAlzheimer's is the gradual loss of memory and memories that radically changes the whole person. However, it is possible that soon we will be able to cope with this. At least, according to reports, a group of experts from France and India was able, during a series of experiments, to fully restore long-term memory in laboratory animals with Alzheimer's disease and restore broken neural connections in the brain.
The team of experts from the department is responsible for the development.molecular biology and genetics Center for Advanced Research named. Jawaharlal Nehru (JNCASR) led by Professor Tapas Kundu. They managed to create a molecule that activates 2 enzymes in the brain - acetyltransferase of histone CBP and p300, which are responsible for the formation of neural connections.
“We wondered: if a molecule can improve memory in healthy mice, can it restore lost memory in mice with Alzheimer's disease? We found a molecule that activates two enzymes in sick mice and produces new neurons. In addition, 81 genes whose expression was suppressed in mice with Alzheimer's disease were activated to normal. In addition to fully recovering lost memory, we also studied other symptoms of Alzheimer's disease. ”Said Professor Kundu in an interview with Journal of Neuroscience.
Researchers believe that mostClinical trials of Alzheimer's disease have failed because memory impairment occurs in the later stages, when the brain is already affected by abnormal protein deposits and has damaged neural connections. In the course of the work, scientists found the opportunity to reverse damage and restore neural connections.
“There is a possibility that the molecule, byto a lesser extent, it can delay the development of cognitive dysfunction. In addition, in laboratory animals, we did not observe the development of signs of progressive brain damage. We are currently studying mice with Alzheimer's disease, which is already a year old. And the first results are encouraging. Long-term memory in animals does not suffer. ”
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