One of the worst diseases to studyThe mechanism of which the main forces of medical science are directed is Alzheimer's disease, annually claiming thousands of lives. An insidious disease gradually deprives a person of memory, and in the later stages the patient loses the ability to speak, navigate in space and, ultimately, dies. Researchers all over the world are working to identify an effective cure for the disease, which by 20150 threatens to infect up to 100 million people worldwide.
Scientists from Germany working at the Institutestudies of stroke and dementia in Munich, revealed a pattern capable of creating protection for brain cells from neurodegeneration. It turned out that increasing the concentration of TREM2 protein, brain cells more effectively resist the development of insidious disease at various stages of its development.
A study in mice revealed thatproduced by the immune cells of the brain, microglia, the TREM2 protein leads to a decrease in the number of toxic plaques in the brain that form during the development of Alzheimer's disease.
The development of the experiment involved the study ofthe effect of TREM2 protein on the fight against Alzheimer's in humans. For several years, scientists have studied the pattern between protein concentration in cerebrospinal fluid in 385 patients prone to various stages of Alzheimer's disease.
As a result of many years of observation, doctors cameto the conclusion that increasing the concentration of TREM2 increases the chances of patients in the fight against an invincible disease so far. It was found that a higher protein content stabilizes memory at various stages of the disease, and also reduces the likelihood of damage to the hippocampus, the part of the brain responsible for the learning and memorization process.
The body itself begins to increase productionTREM2 protein in the early stages of Alzheimer's nucleation. However, the amount of protein produced in the cerebrospinal fluid is not enough to effectively inhibit the development of the disease.
Detection of a substance capable of combatingAlzheimer at different stages of its development, allows you to develop new treatment methods. At this stage, scientists are seeking to detect antibodies that can stimulate the production of TREM2 protein, which enhances the protective functions of the brain.
Earlier, scientists from the United States, studying the effect of microglia on the development of Alzheimer's, came to the conclusion that the absence of microglia leads to the cessation of the production of toxic plaques characteristic of an insidious disease.