Patients with type 1 diabetes on average annuallyyou have to do 700-1000 insulin injections. The hormonal acromegaly causes people to go to the doctors and get very painful injections in the muscles once a month. Some people with multiple sclerosis use interferon beta injections three times a week. Not everyone likes to give injections. Therefore, scientists are trying to develop a more "humane" replacement of needles and syringes. One of these recent developments is the RaniPill smart capsule.
Its creator is an Indian inventor.various medical devices Mir Imran (has more than 400 patents of various inventions). He spent several years working on a new method of delivering the right medicine to the body without having to use painful injections.
Patient who wants to take advantageRaniPill, should simply swallow a capsule, just like a regular pill. Once in the stomach and reacting with its acidic environment, the capsule shell dissolves, leading to the mixing of the two chemicals contained in the capsule and the release of carbon dioxide. The gas will inflate a small sphere inside the capsule, under pressure from which a needle will be pushed out of the capsule to inject the drug directly into the wall of the stomach or intestines. The latter does not contain pain receptors, but it is densely littered with a network of vessels where the medicine will immediately fall.
The capsule itself, like all its constituent parts,including needles, made of biodegradable material. According to the developer, some fragments that did not have time to decompose will come out within 1-4 days along with the digested food.
During the experiments it was demonstrated thatusing RaniPill does not cause problems when swallowed, passes through the digestive tract and even when inflating the sphere and the needles are triggered.
Tests of the "smart capsule" RaniPill with variouspotentially useful drugs, including insulin, were performed on hundreds of experimental animals. All were successful. In addition, the tests with the participation of 20 volunteer people divided into two groups were successfully completed. However, in this case, the Imran team did without drugs, only checking the sensations of volunteers from using the “smart capsule”. One group was asked to take a capsule immediately after eating, the second - on an empty stomach. After people swallowed the capsules they were allowed to walk freely and generally do their usual activities. Every 30 minutes, participants in the experiment were given an X-ray of the gastrointestinal tract, which depicted the progress of the movement of the capsule.
According to Imran himself, all volunteersagreed that the capsule is easy to swallow. They all said that they really did not feel any pain or discomfort from the hidden injection. The developer himself adds that he has “taken several capsules” for verification. At the same time, he swallowed some without water. Tests also showed that food does not create any problems for work, and then subsequent digestion of the capsule. However, in people who took it after meals, the passage of the capsule through the gastrointestinal tract occurred a little longer than those who took it on an empty stomach.
Interestingly, Imran calls his invention a robot, although there are no electronic and metal parts in the “smart capsule”.
“Despite the fact that she has no“ electronic brains ”, she works and performs the only mechanical function assigned to her in the autonomous mode,” the inventor comments.
At the next stage, tests will be conducted with real patients and real drugs.
In addition, the developer plans to add his"Smart capsule" is also a small wireless sensor that will give a signal as soon as the drug is delivered to the target. This will allow doctors to monitor the patient's medication regimen and, if necessary, receive a message on a mobile device that the person has missed a dose of the drug.
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