Recently, scientists are increasingly talking aboutthe dangers of antibiotic-resistant bacteria. Moreover, if earlier the balance in this struggle was leaning towards pharmacists, now more and more microorganisms have begun to adapt faster. And you need to change not only the approach to creating new types of antibiotics, but also change the principles of drug delivery. One of them may be the latest nanoset, which not only kills bacteria more efficiently, but also provides wound healing.
How does a drug delivery nanogrid work?
Researchers from flinders university and theircolleagues in Japan have created a special nanoset. The size of the nanoscale itself is 20 centimeters long and 15 centimeters wide. A net of fibers with a thickness of only 200 nanometers is woven. Inside the mesh fibers there is a hollow core filled with negatively charged gold nanoparticles, as well as antibiotics colistin and vancomycin.
To deliver antibiotics to a specificthe grid region, gold particles were embedded into it using a method called “electrospinning” (approx. ed. electrospinning is a method of producing fibers as a result of the action of electricity on a charged stream of a polymer solution). Thanks to this, we can create new, more effective types of medicines. - say the authors of the work.
But what is the plus of this approach? In fact, everything is quite simple: small charged gold nanoparticles regulate the release of antibiotics from the nanoscale. Adding nanoparticles causes the antibiotic to “migrate” to the center of each fiber (there are a lot of them in the structure of the network itself), which makes it possible to evenly distribute the antibiotic exit from the nanoscale over the entire surface. Thus, the entire colony of bacteria is subjected to a one-time “attack”, which significantly increases the effectiveness of the action. If you are interested in this topic - subscribe to us on Yandex.Zen. There regularly appear materials that cannot be found on the site.
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The effectiveness of the invention has been tested onlaboratory animals for 14 days. Researchers have studied how drugs can affect the growth of E. coli (E. coli). The targeted action of the drug significantly reduced the concentration of antibiotics for the effective destruction of bacteria. That is, during the experiment, to destroy the bacteria required much less drugs "on the grid" than if scientists used traditional methods of administration.
Now experts aim to improveits technology. Firstly, they are trying to study other types of metals that could replace gold in the structure of the nanogrid. And the point here is not even that gold is a precious metal. It is possible that other metals or their alloys will allow more precise control of the flow of drugs.
Secondly, scientists are testing other species with might and mainantibiotics. But there should be no problems with this. In theory, the grid can be "filled" with any drugs. It is worth noting that such a grid is indeed a very promising means of therapy. In addition to the very obvious use of it on open wounds on the skin, it can also be tried on during abdominal operations. In addition, a more effective antibiotic action also reduces wound healing time, reducing the likelihood of relapse.