Scientists WFIRM (Institute of Regenerative MedicineWake Forest) developed a mobile device for skin bioprinting. The gadget for the first time allows you to apply 2-layer skin directly on the wound. The development will help get rid of even non-healing and chronically wounds, such as burn injuries or diabetic ulcers. It is particularly relevant in war, where burns are responsible for 10 to 30 percent of the military casualties of soldiers.
Associate Professor WFIRM Sean Murphy commentedresults. In his opinion, the mobility of the technology and the possibility of its use on the spot are especially important. By scanning and measuring wounds, the system allows cells to be placed directly in the area where they are needed.
In the skin, the main cells are epidermal.keratinocytes and dermal fibroblasts. They are easy to isolate from a small biopsy of whole tissue and then expand. Fibroblasts synthesize collagen and extracellular matrix, which are critical in the wound healing process. And keratinocytes predominate in the epidermis, the uppermost skin layer.
Mixed with hydrogel, the cells are placed in a bioprinter. A technology embedded in it that processes images includes a device that scans a wound. It transmits information to the software, telling the printheads which cells exactly need to be delivered to the wound, layer by layer.
The process copies and also accelerates the formation of the natural structure and normal functioning of the skin. Scientists have shown how their system works by printing the skin directly on preclinical models.