Do you have any sudden bouts of headache,accompanied by nausea and high sensitivity to light and sounds? This form of headache is known as migraine and about 20% of Russia's population suffers from it. It is believed that this disease is one of the most common causes of people's inability to work, because with such pain a person can only lie in bed. In addition, in some cases it is difficult to get rid of it, since drugs effective against it are contraindicated for people with diseases of the cardiovascular system. However, soon people will suffer from severe headaches much less - a medicine has been created that is suitable for almost all people.
A new medicine called urogeptant, but onit is not currently approved by the US Food and Drug Administration (FDA). However, it proved to be effective in three clinical trials with 1,686 participants who experienced migraines 2 to 8 times a month. They were given the task of taking urogeptant within 4 hours after the onset of the first attacks of severe headache. If the drug did not help, volunteers were allowed to drink a second tablet, and in the case of complete inefficiency of the medicine, people drank what helped them before.
How to get rid of a headache?
The results of the study were published inJAMA Science Journal. Scientists found that the drug eliminated severe headache within two hours in 20% of subjects. After taking the second pill, even more people got rid of migraine. Thanks to these observations, the researchers came to the conclusion that to eliminate a headache, you need to drink at least 50 milligrams of urogeptant.
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It is worth noting that the new medicine isfar from the most effective. Since the 1990s, the so-called triptans have been used to treat migraine, which cope with their task in 75% of cases. This class of medication acts on serotonin in the brain, a low content of which is considered one of the causes of pain. The class of drugs is effective, but it narrows the blood vessels, therefore it is contraindicated in people with cardiovascular diseases.
Unlike triptans, urogeptants acton a substance called CGRP, which also plays a large role in the occurrence and spread of severe headache. However, it does not affect the width of the vessels, so it can be taken by almost all patients. Only in some cases it may not work, but it’s better than not having a chance to quickly get rid of the debilitating pain in the head, which prevents you from doing important things.
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When will the new medicine be approved and how muchit will cost while no one knows. At the moment, there are other modern anti-migraine remedies like Aimovig developed in 2018. It also acts on a substance called CGRP and has been well demonstrated in clinical trials. Only now the medicine is injected in the form of regular injections every month, and a year of such treatment costs patients $ 6900. And this, by the way, is about 400,000 rubles.