Research

Found a way to destroy the double protection of bacteria against antibiotics

Since the discovery of antibiotics in 1929many years have passed, and during this time dangerous bacteria have learned to defend themselves against their main killers. They have developed protective mechanisms, and if scientists do not find effective ways to circumvent them, mankind can once again become vulnerable to a huge number of diseases. In some bacteria, the protection consists of as many as two layers - good, researchers from Thomas Jefferson University have found a way to destroy them at once.

Two layers of protection, for example, have intestinalwand and salmonella. If the antibiotic passes through one layer of the cell membrane, the second layer will definitely push it back. However, there is one loophole - proteins that are important for the functioning of cells, are produced by transport RNA, by changing the structure of which it is possible to provoke errors.

To prove this, researchers have createdE. coli and Salmonella engineering strains, depriving them of transport RNA of a specific chemical part. Having "defective" molecules, bacteria could not develop protective proteins, and their cell membranes lost their cohesion. Consequently, more antibiotic molecules could pass through them, and the bacteria died much faster.

We have proven that interfering with a moleculetransport RNA harms the ability of the bacterial cell to produce membrane proteins necessary for protection against antibiotics. The rate of destruction of bacteria is extremely important - the longer the bacteria die, the more likely the development of resistance.

I-Ming Hou, Research Team Leader

Now scientists are more ambitioustask - they need to develop a way to change the structure of transport RNA. The bacteria used in the experiment were designed specifically, and in nature they still produce excellent protective proteins.

It is noteworthy that some bacteria may even sacrifice themselves to save the colonies. How it happens, read in our material.

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