Research

Created substances that can trigger tissue regeneration

Restorative abilities of our bodyvery high. However, this is only true if we are talking about minor damage. The same deep cuts after healing often heal not with ordinary skin, but with coarse scar tissue. Scientists around the world are regularly looking for a way to improve the regenerative capabilities of the human body (especially since there are many such examples in the animal world). And, it is entirely possible that a group of researchers from Canada succeeded. If you are interested in this topic, be sure to subscribe to our news telegram channel.

The authors of the work on the creation of a substance that triggers tissue regeneration. Stefan Angers (left) and Sahdev Sidhu (sparva)

How to start the process of tissue regeneration

Surprisingly, scientists made their discoverythe process of studying the antibodies that the body produces to fight infections. This is not the first case in world practice when antibodies are "converted" into drugs. This is due to their ability to bind proteins and thus affect the functioning of living cells. Since proteins are encoded by a specific set of genes, they can easily be created in the laboratory using genomic and protein engineering technologies. According to the researchers, on the basis of antibodies they were able to develop their "improved synthetic analogues."

We in our studies using antibodies,create new molecules that do not exist in nature. But the topic no less than their potential is simply huge, - said one of the authors of the work, professor of the Center for Cellular and Biomolecular Research Donnelly, Sahdev Sidhu. Using available methods, we can create substances that will turn all regenerative medicine upside down. And at the same time it will not be so expensive to produce them.

New substances are called FLAg. They are inherently analogues of Wnt proteins. The fact is that in the body, Wnt proteins trigger the growth and development of stem cells into cells of any other kind. Wnt are very active in the process of embryo formation, but after birth, the activity of these proteins decreases. But why then just not “add” Wnt? Why create analogues?

Salamanders. One of the most amazing creatures on the planet. They can easily grow lost limbs.

In fact, Wnt in the adult body is stillpresent in small quantities and even performs its function. Only this protein is so "powerful" that it can cause uncontrolled cell growth, which will lead to the development of oncology. Therefore, it was necessary to create a substance that would perform the same function, but whose work could easily be regulated. So there was FLAg.

People have been trying to “tighten” proteins for decades.Wnt and make medicine out of them. The problem is that these proteins are designed in such a way that they are difficult to control. Moreover, the lipids in Wnt prevent the dissolution of proteins in water, which makes them unsuitable as medicines.

Naturally, scientists have already conducted a series ofexperiments. When FLAg was added to cell culture, they behaved exactly like Wnt, stimulating cell growth. Thanks to a more “fine-tuning”, it was possible to stimulate the formation of tissue balls obtained from stem cells that resemble the small intestine.

This is interesting: Structures with greater regenerative potential than stem cells have been discovered.

But that is not all. When FLAg was introduced into the gastrointestinal tract of laboratory mice, intestinal stem cells were activated in animals, showing, on the one hand, that the antibodies are stable and functional inside the body, and on the other hand, that simple administration is enough to start the regeneration process. At the same time, scientists claim that they can develop other specific FLAg variants for the regeneration of the lungs, liver, bones and other tissues of our body.