General, Research, Technology

“Brain Cooling” - A New Method for Combating Parkinson's Disease

According to some reports, Alzheimer's diseaseeven from our distant ancestors. In this case, the disease was described only at the beginning of the last century and around the same time the search for a medicine began. Of course, there are significant successes in this area, but, unfortunately, it is still not possible to completely protect or cure our body from this neurodegenerative process. Nevertheless, scientists do not abandon attempts to do this and recently a group of researchers from the University of Queensland began testing a rather promising method.

According to statistics, the diseaseParkinson's is the second most common neurodegenerative disease in the world. About 10 million people suffer from it annually. The main mechanism of the development of the disease is chronic inflammation of brain neurons, accompanied by protein deposition, loss of control over motor activity and other lesions of the central nervous system. It was on the process of inflammation that the assistant professor of the medical faculty Trent Woodroff and professor Matt Cooper decided to pay attention.

“Our team found that a small moleculeThe MCC950 stopped the development of Parkinson in several animal models. "We used this discovery to develop improved drugs of a new type and plan to begin clinical trials by 2020."

The essence of the drug is as follows: the researchers found that in many patients suffering from Alzheimer's disease, the NLRP3 protein complex is a major development factor. It not only causes protein adhesion on inflamed brain cells, but also circulates in the blood. The synthetic MCC950 molecule perceives this protein as a target and blocks it.

"The inflammatory process is associated with an increaselocal temperature, and we can say that the MCC950 molecule “kind of cools the brain”, which stops the development of inflammation and allows neurons to function normally again. In the course of the first experiments on laboratory animals, we were able to achieve a significant restoration of motor activity. ”

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