General

A variety of intestinal microflora may be the secret to healthy life in old age.

As shown by studies conductedby immunologists at the Babraham Institute in Cambridge, transplantation of feces from young mice to old ones can stimulate the intestinal microflora and revitalize the intestinal immune system. A study on this topic was published in the journal Nature Communications. The intestine is one of the organs that are most susceptible to aging, and age-related changes in the intestinal microflora occur in parallel with a decrease in the function of the intestinal immune system.

However, until now it was not known whether these changes are related to each other.

The secrets of a healthy and long life lurking in the stomach

"The microflora of our intestines consists of hundredsdifferent types of bacteria, and they are necessary for our health, play a role in metabolism, brain function and immune response, ”explains lead researcher Dr. Marisa Stebegg. “Our immune system constantly interacts with bacteria in the gastrointestinal tract. As immunologists studying why our immune system stops coping with aging, we are interested in whether the composition of the intestinal microflora can affect the strength of the immune response of the intestine. ”

Putting together young and old mice (mice likethey usually like to try fecal pellets of other mice) or directly transfer feces from young to older mice, the scientists saw that the immune system of the intestine in older mice increased, partially correcting the loss of function associated with age.

"To our surprise, living together savedweakened intestinal immune response in old mice. If you look at the number of immune cells involved, the old mice were found to have an immune response in the intestines, almost indistinguishable from those in younger mice, ”says Michel Linterman, the team leader.

The results show that poor intestinalThe immune response is not irreversible and that response can be enhanced by stimulation with appropriate stimuli and stimuli. In fact, you can turn the clock on the immune system of the intestine, make it more similar to the young version of yourself.

All this confirms the connection between the consequences.aging of the immune system and age-related changes in the intestinal microflora. Also, this study shows that fecal transplants, probiotics, cohabitation and diet can contribute to healthy aging.

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