Antibody use is becoming mainstreaminnovative therapy in the fight against SARS-CoV-2, but the risk of evolutionary "escape of the virus" remains very high and not fully understood. This conclusion was reached by scientists from the Fred Hutchinson Cancer Research Center in Seattle.
The mutation of the coronavirus in humans has been identified yetin mid-November, when viruses that successfully resist some of the antibodies were identified. Mutations took place in different countries. So one mutation comes from the Netherlands and Denmark, where an epidemic has been reported among minks, while another mutation was found in Scotland and Ireland.
The mutation occurs in the receptor binding domainRBD, which is a subunit of a spike protein that allows the virus to enter the cell. Scientists said that one of the mutations hides the virus from a wide range of antibodies, while the other helps viruses "escape" from certain types of antibodies.